BCL2 Antibodies Targeted At Different Epitopes Detect Varying Levels of Protein Expression and Correlate with Frequent Gene Amplification in Diffuse Large B Cell Lymphoma

Patients with aggressive, BCL2 protein-positive (+) diffuse large B-cell lymphoma (DLBCL) often experience rapid disease progression that is refractory to standard therapy. However, there is potential for false-negative staining of BCL2 using the standard monoclonal mouse 124 antibody that hinders t...

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Huvudupphovsmän: Kendrick, Samantha L., Redd, Lucas, Muranyi, Andrea, Henricksen, Leigh A., Stanislaw, Stacey, Smith, Lynette M., Perry, Anamarija M., Fu, Kai, Weisenburger, Dennis D., Rosenwald, Andreas, Ott, German, Gascoyne, Randy D., Jaffe, Elaine S., Campo, Elías, Delabie, Jan, Braziel, Rita M., Cook, James R., Tubbs, Raymond R., Staudt, Louis M., Chan, Wing Chung, Steidl, Christian, Grogan, Thomas M., Rimsza, Lisa M.
Materialtyp: Artigo
Språk:Inglês
Publicerad: 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4197184/
https://ncbi.nlm.nih.gov/pubmed/25090918
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.humpath.2014.06.005
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