Inhibition of AP-1 binding and transcription by gold and selenium involving conserved cysteine residues in Jun and Fos.

Gold(I) salts and selenite, which have diverse therapeutic and biological effects, are noted for their reactivity with thiols. Since the binding of Jun-Jun and Jun-Fos dimers to the AP-1 DNA binding site is regulated in vitro by a redox process involving conserved cysteine residues, we hypothesized...

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Detalles Bibliográficos

Publicado en:	Proc Natl Acad Sci U S A
Principais autores:	Handel, M L, Watts, C K, deFazio, A, Day, R O, Sutherland, R L
Formato:	Artigo
Idioma:	Inglês
Publicado:	National Academy of Sciences 1995
Assuntos:	Research Article
Acceso en liña:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41971/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753832/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.10.4497
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