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Cardiac ryanodine receptor activation by a high Ca(2+) store load is reversed in a reducing cytoplasmic redox environment
Here, we report the impact of redox potential on isolated cardiac ryanodine receptor (RyR2) channel activity and its response to physiological changes in luminal [Ca(2+)]. Basal leak from the sarcoplasmic reticulum is required for normal Ca(2+) handling, but excess diastolic Ca(2+) leak attributed t...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Company of Biologists
2014
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4197090/ https://ncbi.nlm.nih.gov/pubmed/25146393 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.156760 |
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