L-Endoglin Overexpression Increases Renal Fibrosis after Unilateral Ureteral Obstruction

Transforming growth factor-β (TGF-β) plays a pivotal role in renal fibrosis. Endoglin, a 180 KDa membrane glycoprotein, is a TGF-β co-receptor overexpressed in several models of chronic kidney disease, but its function in renal fibrosis remains uncertain. Two membrane isoforms generated by alternati...

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Main Authors: Oujo, Bárbara, Muñoz-Félix, José M., Arévalo, Miguel, Núñez-Gómez, Elena, Pérez-Roque, Lucía, Pericacho, Miguel, González-Núñez, María, Langa, Carmen, Martínez-Salgado, Carlos, Perez-Barriocanal, Fernando, Bernabeu, Carmelo, Lopez-Novoa, José M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196986/
https://ncbi.nlm.nih.gov/pubmed/25313562
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110365
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