Identification of regions in multiple sequence alignments thermodynamically suitable for targeting by consensus oligonucleotides: application to HIV genome

BACKGROUND: Computer programs for the generation of multiple sequence alignments such as "Clustal W" allow detection of regions that are most conserved among many sequence variants. However, even for regions that are equally conserved, their potential utility as hybridization targets varie...

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Detalhes bibliográficos
Main Authors: Matveeva, Olga V, Foley, Brian T, Nemtsov, Vladimir A, Gesteland, Raymond F, Matsufuji, Senya, Atkins, John F, Ogurtsov, Alexei Y, Shabalina, Svetlana A
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2004
Assuntos:
Methodology Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC419695/
https://ncbi.nlm.nih.gov/pubmed/15115544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2105-5-44
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