Hedgehog Pathway Modulation by Multiple Lipid Binding Sites on the Smoothened Effector of Signal Response

Hedgehog (Hh) signaling during development and in postembryonic tissues requires activation of the 7TM oncoprotein Smoothened (Smo), by mechanisms that may involve endogenous lipidic modulators. Exogenous Smo ligands previously identified include the plant sterol cyclopamine (and its therapeutically...

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Autors principals: Myers, Benjamin R., Sever, Navdar, Chong, Yong Chun, Kim, James, Belani, Jitendra D., Rychnovsky, Scott, Bazan, J. Fernando, Beachy, Philip A.
Format: Artigo
Idioma:Inglês
Publicat: 2013
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196939/
https://ncbi.nlm.nih.gov/pubmed/23954590
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.devcel.2013.07.015
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