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Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo

Platelet-derived growth factor (PDGF) and its receptors (PDGFR), including PDGFRα and PDGFRβ, play important roles in tumorigenesis, tumor progression, and the regulation of stromal cell function. Constitutive activation of PDGFR signaling, gene rearrangement, and activating mutations of PDGFR have...

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Detalhes bibliográficos
Main Authors: Wang, Ping, Song, Liqiang, Ge, Hui, Jin, Pule, Jiang, Yifang, Hu, Wenxia, Geng, Nan
Formato: Artigo
Idioma:Inglês
Publicado em: Dove Medical Press 2014
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196792/
https://ncbi.nlm.nih.gov/pubmed/25328409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S68773
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