Crenolanib, a PDGFR inhibitor, suppresses lung cancer cell proliferation and inhibits tumor growth in vivo

Platelet-derived growth factor (PDGF) and its receptors (PDGFR), including PDGFRα and PDGFRβ, play important roles in tumorigenesis, tumor progression, and the regulation of stromal cell function. Constitutive activation of PDGFR signaling, gene rearrangement, and activating mutations of PDGFR have...

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Bibliografiske detaljer
Main Authors: Wang, Ping, Song, Liqiang, Ge, Hui, Jin, Pule, Jiang, Yifang, Hu, Wenxia, Geng, Nan
Format: Artigo
Sprog:Inglês
Udgivet: Dove Medical Press 2014
Fag:
Original Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196792/
https://ncbi.nlm.nih.gov/pubmed/25328409
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S68773
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