Phase 1 Trial of Temsirolimus in Combination with Irinotecan and Temozolomide in Children, Adolescents and Young Adults with Relapsed or Refractory Solid Tumors: A Children’s Oncology Group Study

BACKGROUND: mTOR inhibitors have activity in pediatric tumor models. A phase I trial of the mTOR inhibitor temsirolimus (TEM) with irinotecan (IRN) and temozolomide (TMZ) was conducted in children with recurrent/refractory solid tumors, including central nervous system (CNS) tumors. METHODS: Escalat...

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Bibliographic Details
Main Authors: Bagatell, R, Norris, RE, Ingle, AM, Ahern, CH, Voss, S, Fox, E, Little, A, Weigel, B, Adamson, PC, Blaney, SM
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196713/
https://ncbi.nlm.nih.gov/pubmed/24249672
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/pbc.24874
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