Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cells

Cystic fibrosis (CF) is a fatal, autosomal, recessive genetic disease that is characterized by profound lung inflammation. The inflammatory process is believed to be caused by massive overproduction of the proinflammatory protein IL-8, and the high levels of IL-8 in the CF lung are therefore believe...

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Autori principali: Srivastava, Meera, Eidelman, Ofer, Zhang, Jian, Paweletz, Cloud, Caohuy, Hung, Yang, QingFeng, Jacobson, Kenneth A., Heldman, Eliahu, Huang, Wei, Jozwik, Catherine, Pollard, Bette S., Pollard, Harvey B.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2004
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC419668/
https://ncbi.nlm.nih.gov/pubmed/15136726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402030101
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