Transcriptional regulation of the p73 gene by Nrf-2 and promoter CpG methylation in human breast cancer

To understand the transcriptional regulation of p73 by promoter methylation and Nrf-2 in breast carcinogenesis, ChIP assay indicated that Nrf-2 can bind to both promoters and can activate the transcription of TAp73 and ΔΝp73 in MCF-7 cell line, knockdown of Nrf-2 gene resulted in an abrogation of TA...

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Detalhes bibliográficos
Main Authors: Lai, Jing, Nie, Weiwei, Zhang, Wenwen, Wang, Yucai, Xie, Ruilian, Wang, Yanru, Gu, Jun, Xu, Jing, Song, Wei, Yang, Fang, Huang, Guichun, Cao, Peng, Guan, Xiaoxiang
Formato: Artigo
Idioma:Inglês
Publicado em: Impact Journals LLC 2014
Assuntos:
Research Paper
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4196172/
https://ncbi.nlm.nih.gov/pubmed/25071010
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