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Cloning, baculovirus expression, and characterization of a second mouse prolyl 4-hydroxylase alpha-subunit isoform: formation of an alpha 2 beta 2 tetramer with the protein disulfide-isomerase/beta subunit.

Prolyl 4-hydroxylase (EC 1.14.11.2) catalyzes the posttranslational formation of 4-hydroxyproline in collagens. The vertebrate enzyme is an alpha 2 beta 2 tetramer, the beta subunit of which is a highly unusual multifunctional polypeptide, being identical to protein disulfide-isomerase (EC 5.3.4.1)....

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Principais autores: Helaakoski, T, Annunen, P, Vuori, K, MacNeil, I A, Pihlajaniemi, T, Kivirikko, K I
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 1995
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC41957/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7753822/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.92.10.4427
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