Immunogenicity Evaluation of a Rationally Designed Polytope Construct Encoding HLA-A*0201 Restricted Epitopes Derived from Leishmania major Related Proteins in HLA-A2/DR1 Transgenic Mice: Steps toward Polytope Vaccine

BACKGROUND: There are several reports demonstrating the role of CD8 T cells against Leishmania species. Therefore peptide vaccine might represent an effective approach to control the infection. We developed a rational polytope-DNA construct encoding immunogenic HLA-A2 restricted peptides and validat...

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Main Authors: Seyed, Negar, Taheri, Tahereh, Vauchy, Charline, Dosset, Magalie, Godet, Yann, Eslamifar, Ali, Sharifi, Iraj, Adotevi, Olivier, Borg, Christophe, Rohrlich, Pierre Simon, Rafati, Sima
Format: Artigo
Language:Inglês
Published: Public Library of Science 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195657/
https://ncbi.nlm.nih.gov/pubmed/25310094
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0108848
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