Action Potential-Evoked Calcium Release Is Impaired in Single Skeletal Muscle Fibers from Heart Failure Patients

BACKGROUND: Exercise intolerance in chronic heart failure (HF) has been attributed to abnormalities of the skeletal muscles. Muscle function depends on intact excitation-contraction coupling (ECC), but ECC studies in HF models have been inconclusive, due to deficiencies in the animal models and tool...

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Main Authors: DiFranco, Marino, Quiñonez, Marbella, Shieh, Perry, Fonarow, Gregg C., Cruz, Daniel, Deng, Mario C., Vergara, Julio L., Middlekauff, Holly R.
Formato: Artigo
Idioma:Inglês
Publicado: Public Library of Science 2014
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Research Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195605/
https://ncbi.nlm.nih.gov/pubmed/25310188
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109309
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