Stratified randomization controls better for batch effects in 450K methylation analysis: a cautionary tale

Background: Batch effects in DNA methylation microarray experiments can lead to spurious results if not properly handled during the plating of samples. Methods: Two pilot studies examining the association of DNA methylation patterns across the genome with obesity in Samoan men were investigated for...

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Detalhes bibliográficos
Main Authors: Buhule, Olive D., Minster, Ryan L., Hawley, Nicola L., Medvedovic, Mario, Sun, Guangyun, Viali, Satupaitea, Deka, Ranjan, McGarvey, Stephen T., Weeks, Daniel E.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Genetics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4195366/
https://ncbi.nlm.nih.gov/pubmed/25352862
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fgene.2014.00354
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