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Identification of Ald6p as the target of a class of small-molecule suppressors of FK506 and their use in network dissection
FK506 inhibits the Ca(2+)/calmodulin-dependent protein phosphatase calcineurin, which plays a critical role in yeast subjected to salt stress. A chemical genetic screen for small molecules that suppress growth inhibition by high NaCl plus FK506 identified a structurally related class of suppressors...
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| Autori principali: | , |
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| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2004
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC419523/ https://ncbi.nlm.nih.gov/pubmed/15146068 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.0402317101 |
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