The IL-12Rβ2 gene functions as a tumor suppressor in human B cell malignancies

The IL-12Rβ2 gene is expressed in human mature B cell subsets but not in transformed B cell lines. Silencing of this gene may be advantageous to neoplastic B cells. Our objective was to investigate the mechanism(s) and the functional consequence(s) of IL-12Rβ2 gene silencing in primary B cell tumors...

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Hauptverfasser: Airoldi, Irma, Di Carlo, Emma, Banelli, Barbara, Moserle, Lidia, Cocco, Claudia, Pezzolo, Annalisa, Sorrentino, Carlo, Rossi, Edoardo, Romani, Massimo, Amadori, Alberto, Pistoia, Vito
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2004
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC419484/
https://ncbi.nlm.nih.gov/pubmed/15173892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI200420303
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