High prevalence of chitotriosidase deficiency in Peruvian Amerindians exposed to chitin-bearing food and enteroparasites

The human genome encodes a gene for an enzymatically active chitinase (CHIT1) located in a single copy on Chromosome 1, which is highly expressed by activated macrophages and in other cells of the innate immune response. Several dysfunctional mutations are known in CHIT1, including a 24-bp duplicati...

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Huvudupphovsmän: Manno, N., Sherratt, S., Boaretto, F., Coico, F. Mejìa, Camus, C. Espinoza, Campos, C. Jara, Musumeci, S., Battisti, A., Quinnell, R.J., León, J. Mostacero, Vazza, G., Mostacciuolo, M.L., Paoletti, M.G., Falcone, F.H.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Elsevier Applied Science Publishers 2014
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC4194353/
https://ncbi.nlm.nih.gov/pubmed/25256524
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.carbpol.2014.07.011
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