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TOR signaling couples oxygen sensing to lifespan in C. elegans
Metazoans adapt to a low oxygen environment (hypoxia) through activation of stress response pathways. Here we report that transient hypoxia exposure extends lifespan in C. elegans through mitochondrial ROS-dependent regulation of the nutrient sensing kinase TOR and its upstream activator RHEB-1. The...
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| Main Authors: | , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2014
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4194168/ https://ncbi.nlm.nih.gov/pubmed/25284791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2014.08.075 |
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