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Hypometabolism and hypothermia in the rat model of endotoxic shock: independence of circulatory hypoxia

We tested the hypothesis that development of hypothermia instead of fever in endotoxic shock is consequential to hypoxia. Endotoxic shock was induced by bacterial lipopolysaccharide (LPS, 500 μg kg(−1) i.v.) in rats at an ambient temperature of 22°C. A β(3)-adrenergic agonist known to activate metab...

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Bibliografiske detaljer
Main Authors: Corrigan, Joshua J, Fonseca, Monique T, Flatow, Elizabeth A, Lewis, Kevin, Steiner, Alexandre A
Format: Artigo
Sprog:Inglês
Udgivet: Blackwell Science Inc 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192710/
https://ncbi.nlm.nih.gov/pubmed/24951620
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1113/jphysiol.2014.277277
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