Phosphatase CD45 Both Positively and Negatively Regulates T Cell Receptor Phosphorylation in Reconstituted Membrane Protein Clusters

T cell receptor (TCR) phosphorylation requires the kinase Lck and phosphatase CD45. CD45 activates Lck by dephosphorylating an inhibitory tyrosine of Lck to relieve autoinhibition. However, CD45 also dephosphorylates the TCR, and the spatial exclusion of CD45 from TCR clustering in the plasma membra...

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Autores principales: Furlan, Gabriela, Minowa, Takashi, Hanagata, Nobutaka, Kataoka-Hamai, Chiho, Kaizuka, Yoshihisa
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192502/
https://ncbi.nlm.nih.gov/pubmed/25128530
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.574319
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