Regression of Replication Forks Stalled by Leading-strand Template Damage: I. BOTH RecG AND RuvAB CATALYZE REGRESSION, BUT RuvC CLEAVES THE HOLLIDAY JUNCTIONS FORMED BY RecG PREFERENTIALLY

The orderly progression of replication forks formed at the origin of replication in Escherichia coli is challenged by encounters with template damage, slow moving RNA polymerases, and frozen DNA-protein complexes that stall the fork. These stalled forks are foci for genomic instability and must be r...

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Bibliographic Details
Main Authors: Gupta, Sankalp, Yeeles, Joseph T. P., Marians, Kenneth J.
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2014
Subjects:
DNA and Chromosomes
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192490/
https://ncbi.nlm.nih.gov/pubmed/25138216
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.587881
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