Metabolic dysfunction drives a mechanistically distinct pro-inflammatory phenotype in adipose tissue macrophages

Adipose tissue macrophage (ATM)-driven inflammation plays a key role in insulin resistance; however, factors activating ATMs are poorly understood. Using a proteomics approach, we show that markers of classical activation are absent on ATMs from obese humans, but readily detectable on airway macroph...

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Main Authors: Kratz, Mario, Coats, Brittney R., Hisert, Katherine B., Hagman, Derek, Mutskov, Vesco, Peris, Eduard, Schoenfelt, Kelly Q., Kuzma, Jessica N., Larson, Ilona, Billing, Peter S., Landerholm, Robert W., Crouthamel, Matthew, Gozal, David, Hwang, Seungmin, Singh, Pradeep, Becker, Lev
Format: Artigo
Jezik:Inglês
Izdano: 2014
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4192131/
https://ncbi.nlm.nih.gov/pubmed/25242226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cmet.2014.08.010
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