Sildenafil Does Not Improve Cardiomyopathy in Duchenne/Becker Muscular Dystrophy

OBJECTIVE: Duchenne and Becker muscular dystrophy (DBMD) are allelic disorders caused by mutations in dystrophin. Adults with DBMD develop life-threatening cardiomyopathy. Inhibition of phosphodiesterase 5 (PDE5) improves cardiac function in mouse models of DBMD. To determine if the PDE5-inhibitor s...

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Autores principales: Leung, Doris G., Herzka, Daniel A., Thompson, W. Reid, He, Bing, Bibat, Genila, Tennekoon, Gihan, Russell, Stuart D., Schuleri, Karl H., Lardo, Albert C., Kass, David A., Thompson, Richard E., Judge, Daniel P., Wagner, Kathryn R.
Formato: Artigo
Lenguaje:Inglês
Publicado: 2014
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191982/
https://ncbi.nlm.nih.gov/pubmed/25042693
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/ana.24214
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