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Nuclear Expression of β-Catenin Promotes RB Stability and Resistance to TNF-Induced Apoptosis in Colon Cancer Cells

Tumor necrosis factor (TNF)-α promotes tumor development under chronic inflammation. Because TNF also activates caspase-8, selective inhibition of TNF-induced extrinsic apoptosis would be required for inflammation-associated tumor growth. In a mouse model of inflammation-associated colon carcinogene...

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Detalhes bibliográficos
Main Authors: Han, Jinbo, Soletti, Rossana C., Sadarangani, Anil, Sridevi, Priya, Ramirez, Michael E., Eckmann, Lars, Borges, Helena L., Wang, Jean Y.J.
Formato: Artigo
Idioma:Inglês
Publicado em: 2013
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191841/
https://ncbi.nlm.nih.gov/pubmed/23339186
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-12-0670
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