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Genome-wide association study identifies multiple susceptibility loci for pancreatic cancer

We performed a multistage genome-wide association study (GWAS) including 7,683 individuals with pancreatic cancer and 14,397 controls of European descent. Four new loci reached genome-wide significance: rs6971499 at 7q32.3 (LINC-PINT; per-allele odds ratio [OR] = 0.79; 95% confidence interval [CI] =...

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Main Authors: Wolpin, Brian M., Rizzato, Cosmeri, Kraft, Peter, Kooperberg, Charles, Petersen, Gloria M., Wang, Zhaoming, Arslan, Alan A., Beane-Freeman, Laura, Bracci, Paige M., Buring, Julie, Canzian, Federico, Duell, Eric J., Gallinger, Steven, Giles, Graham G., Goodman, Gary E., Goodman, Phyllis J., Jacobs, Eric J., Kamineni, Aruna, Klein, Alison P., Kolonel, Laurence N., Kulke, Matthew H., Li, Donghui, Malats, Núria, Olson, Sara H., Risch, Harvey A., Sesso, Howard D., Visvanathan, Kala, White, Emily, Zheng, Wei, Abnet, Christian C., Albanes, Demetrius, Andreotti, Gabriella, Austin, Melissa A., Barfield, Richard, Basso, Daniela, Berndt, Sonja I., Boutron-Ruault, Marie-Christine, Brotzman, Michelle, Büchler, Markus W., Bueno-de-Mesquita, H. Bas, Bugert, Peter, Burdette, Laurie, Campa, Daniele, Caporaso, Neil E., Capurso, Gabriele, Chung, Charles, Cotterchio, Michelle, Costello, Eithne, Elena, Joanne, Funel, Niccola, Gaziano, J. Michael, Giese, Nathalia A., Giovannucci, Edward L., Goggins, Michael, Gorman, Megan J., Gross, Myron, Haiman, Christopher A., Hassan, Manal, Helzlsouer, Kathy J., Henderson, Brian E., Holly, Elizabeth A., Hu, Nan, Hunter, David J., Innocenti, Federico, Jenab, Mazda, Kaaks, Rudolf, Key, Timothy J., Khaw, Kay-Tee, Klein, Eric A., Kogevinas, Manolis, Krogh, Vittorio, Kupcinskas, Juozas, Kurtz, Robert C., LaCroix, Andrea, Landi, Maria T., Landi, Stefano, Le Marchand, Loic, Mambrini, Andrea, Mannisto, Satu, Milne, Roger L., Nakamura, Yusuke, Oberg, Ann L., Owzar, Kouros, Patel, Alpa V., Peeters, Petra H. M., Peters, Ulrike, Pezzilli, Raffaele, Piepoli, Ada, Porta, Miquel, Real, Francisco X., Riboli, Elio, Rothman, Nathaniel, Scarpa, Aldo, Shu, Xiao-Ou, Silverman, Debra T., Soucek, Pavel, Sund, Malin, Talar-Wojnarowska, Renata, Taylor, Philip R., Theodoropoulos, George E., Thornquist, Mark, Tjønneland, Anne, Tobias, Geoffrey S., Trichopoulos, Dimitrios, Vodicka, Pavel, Wactawski-Wende, Jean, Wentzensen, Nicolas, Wu, Chen, Yu, Herbert, Yu, Kai, Zeleniuch-Jacquotte, Anne, Hoover, Robert, Hartge, Patricia, Fuchs, Charles, Chanock, Stephen J., Stolzenberg-Solomon, Rachael S., Amundadottir, Laufey T.
פורמט: Artigo
שפה:Inglês
יצא לאור: 2014
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גישה מקוונת:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191666/
https://ncbi.nlm.nih.gov/pubmed/25086665
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.3052
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