Identification of the First Inhibitor of the GBP1:PIM1 Interaction. Implications for the Development of a New Class of Anticancer Agents against Paclitaxel Resistant Cancer Cells

[Image: see text] Class III β-tubulin plays a prominent role in the development of drug resistance to paclitaxel by allowing the incorporation of the GBP1 GTPase into microtubules. Once in the cytoskeleton, GBP1 binds to prosurvival kinases such as PIM1 and initiates a signaling pathway that induces...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Andreoli, Mirko, Persico, Marco, Kumar, Ajay, Orteca, Nausicaa, Kumar, Vineet, Pepe, Antonella, Mahalingam, Sakkarapalayam, Alegria, Antonio E., Petrella, Lella, Sevciunaite, Laima, Camperchioli, Alessia, Mariani, Marisa, Di Dato, Antonio, Novellino, Ettore, Scambia, Giovanni, Malhotra, Sanjay V., Ferlini, Cristiano, Fattorusso, Caterina
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Chemical Society 2014
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191604/
https://ncbi.nlm.nih.gov/pubmed/25211704
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/jm5009902
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