TERT Promoter Mutations Are a Major Indicator of Poor Outcome in Differentiated Thyroid Carcinomas

CONTEXT: Telomerase promoter mutations (TERT) were recently described in follicular cell-derived thyroid carcinomas (FCDTC) and seem to be more prevalent in aggressive cancers. OBJECTIVES: We aimed to evaluate the frequency of TERT promoter mutations in thyroid lesions and to investigate the prognos...

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Detalhes bibliográficos
Main Authors: Melo, Miguel, da Rocha, Adriana Gaspar, Vinagre, João, Batista, Rui, Peixoto, Joana, Tavares, Catarina, Celestino, Ricardo, Almeida, Ana, Salgado, Catarina, Eloy, Catarina, Castro, Patrícia, Prazeres, Hugo, Lima, Jorge, Amaro, Teresina, Lobo, Cláudia, Martins, Maria João, Moura, Margarida, Cavaco, Branca, Leite, Valeriano, Cameselle-Teijeiro, José Manuel, Carrilho, Francisco, Carvalheiro, Manuela, Máximo, Valdemar, Sobrinho-Simões, Manuel, Soares, Paula
Formato: Artigo
Idioma:Inglês
Publicado em: Endocrine Society 2014
Assuntos:
Hot Topics in Translational Endocrinology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191548/
https://ncbi.nlm.nih.gov/pubmed/24476079
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/jc.2013-3734
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