Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders

Heme oxygenase-1 (HO-1) is an inducible, detoxifying enzyme that is critical for limiting oxidative stress, inflammation, and cellular injury within the CNS and other tissues. Here, we demonstrate a deficiency of HO-1 expression in the brains of HIV-infected individuals. This HO-1 deficiency correla...

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Detalhes bibliográficos
Main Authors: Gill, Alexander J., Kovacsics, Colleen E., Cross, Stephanie A., Vance, Patricia J., Kolson, Lorraine L., Jordan-Sciutto, Kelly L., Gelman, Benjamin B., Kolson, Dennis L.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Clinical Investigation 2014
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191052/
https://ncbi.nlm.nih.gov/pubmed/25202977
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI72279
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