Plasma fibronectin supports hemostasis and regulates thrombosis

Plasma fibronectin (pFn) has long been suspected to be involved in hemostasis; however, direct evidence has been lacking. Here, we demonstrated that pFn is vital to control bleeding in fibrinogen-deficient mice and in WT mice given anticoagulants. At the site of vessel injury, pFn was rapidly deposi...

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Hauptverfasser: Wang, Yiming, Reheman, Adili, Spring, Christopher M., Kalantari, Jalil, Marshall, Alexandra H., Wolberg, Alisa S., Gross, Peter L., Weitz, Jeffrey I., Rand, Margaret L., Mosher, Deane F., Freedman, John, Ni, Heyu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4191008/
https://ncbi.nlm.nih.gov/pubmed/25180602
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI74630
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