A random six-phase switch regulates pneumococcal virulence via global epigenetic changes

Streptococcus pneumoniae (the pneumococcus) is the world’s foremost bacterial pathogen in both morbidity and mortality. Switching between phenotypic forms (or ‘phases’) that favour asymptomatic carriage or invasive disease was first reported in 1933. Here, we show that the underlying mechanism for s...

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Detalhes bibliográficos
Main Authors: Manso, Ana Sousa, Chai, Melissa H., Atack, John M., Furi, Leonardo, De Ste Croix, Megan, Haigh, Richard, Trappetti, Claudia, Ogunniyi, Abiodun D., Shewell, Lucy K., Boitano, Matthew, Clark, Tyson A., Korlach, Jonas, Blades, Matthew, Mirkes, Evgeny, Gorban, Alexander N., Paton, James C., Jennings, Michael P., Oggioni, Marco R.
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Pub. Group 2014
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190663/
https://ncbi.nlm.nih.gov/pubmed/25268848
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ncomms6055
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