Copper-Based Pulsed Dipolar ESR Spectroscopy as a Probe of Protein Conformation Linked to Disease States

We demonstrate the ability of pulsed dipolar electron spin resonance (ESR) spectroscopy (PDS) to report on the conformation of Cu-Zn superoxide dismutase (SOD1) through the sensitive measurement of dipolar interactions between inherent Cu(2+) ions. Although the extent and the anisotropy of the Cu ES...

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Autori principali: Merz, Gregory E., Borbat, Peter P., Pratt, Ashley J., Getzoff, Elizabeth D., Freed, Jack H., Crane, Brian R.
Natura: Artigo
Lingua:Inglês
Pubblicazione: The Biophysical Society 2014
Soggetti:
Proteins and Nucleic Acids
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190658/
https://ncbi.nlm.nih.gov/pubmed/25296320
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bpj.2014.07.068
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