Synthesis and Structure–Activity Relationships of α-Amino-γ-lactone Ketolides: A Novel Class of Macrolide Antibiotics

[Image: see text] An efficient synthesis of α-amino-γ-lactone ketolide (3) was developed, which provided a versatile intermediate for the incorporation of a variety of aryl and heteroaryl groups onto the C-21 position of clarithromycin via HBTU-mediated amidation. The biological data for this import...

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Detalhes bibliográficos
Main Authors: Pavlović, Dražen, Mutak, Stjepan, Andreotti, Daniele, Biondi, Stefano, Cardullo, Francesca, Paio, Alfredo, Piga, Elisa, Donati, Daniele, Lociuro, Sergio
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2014
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190632/
https://ncbi.nlm.nih.gov/pubmed/25313326
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ml500279k
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