Axitinib and crizotinib combination therapy inhibits bone loss in a mouse model of castration resistant prostate cancer

BACKGROUND: Castration resistant prostate cancer (CRPC) is a leading cause of cancer-related deaths in men. The primary cause of mortality and morbidity in patients is bone metastases and remodeling resulting in osteoblastic and osteolytic lesions. Recently, cabozantinib, a multi-kinase inhibitor (V...

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Hauptverfasser: Eswaraka, Jeetendra, Giddabasappa, Anand, Han, Guangzhou, Lalwani, Kush, Eisele, Koleen, Feng, Zheng, Affolter, Timothy, Christensen, James, Li, Gang
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2014
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4190397/
https://ncbi.nlm.nih.gov/pubmed/25277255
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2407-14-742
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