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Cyclic GMP-AMP Displays Mucosal Adjuvant Activity in Mice
The recently discovered mammalian enzyme cyclic GMP-AMP synthase produces cyclic GMP-AMP (cGAMP) after being activated by pathogen-derived cytosolic double stranded DNA. The product can stimulate STING-dependent interferon type I signaling. Here, we explore the efficacy of cGAMP as a mucosal adjuvan...
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| Main Authors: | , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
Public Library of Science
2014
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4190368/ https://ncbi.nlm.nih.gov/pubmed/25295996 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0110150 |
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