AAV2/8-hSMAD3 gene delivery attenuates aortic atherogenesis, enhances Th2 response without fibrosis, in LDLR-KO mice on high cholesterol diet

BACKGROUND: Inflammation is a key etiologic component in atherogenesis and transforming growth factor beta 1 (TGFβ1) is a well known anti-inflammatory cytokine which potentially might be used to limit it. Yet TGFβ1 is pleiomorphic, causing fibrosis, cell taxis, and under certain circumstances, can e...

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Detalhes bibliográficos
Main Authors: Zhu, Hongqing, Cao, Maohua, Figueroa, Jose A, Cobos, Everado, Uretsky, Barry F, Chiriva-Internati, Maurizio, Hermonat, Paul L
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189750/
https://ncbi.nlm.nih.gov/pubmed/25236373
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12967-014-0252-8
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