Neuroprotective effects of bilobalide on cerebral ischemia and reperfusion injury are associated with inhibition of pro-inflammatory mediator production and down-regulation of JNK1/2 and p38 MAPK activation

BACKGROUND: Mitogen-activated protein kinase (MAPK) signaling pathways are implicated in inflammatory and apoptotic processes of cerebral ischemia and reperfusion (I/R) injury. Hence, MAPK pathways represent a promising therapeutic target. Exploring the full potential of inhibitors of MAPK pathways...

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Detalhes bibliográficos
Main Authors: Jiang, Mingjin, Li, Jing, Peng, Qiuxian, Liu, Yi, Liu, Wei, Luo, Chaohua, Peng, Ju, Li, Junkui, Yung, Ken Kin Lam, Mo, Zhixian
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2014
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189683/
https://ncbi.nlm.nih.gov/pubmed/25256700
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12974-014-0167-6
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