Monosodium urate crystal induced macrophage inflammation is attenuated by chondroitin sulphate: pre-clinical model for gout prophylaxis?

BACKGROUND: Chondroitin Sulphate (CS), a natural glycosaminoglycan of the extracellular matrix, has clinical benefit in symptomatic osteoarthritis but has never been tested in gout. In vitro, CS has anti-inflammatory and positive effects on osteoarthritic chondrocytes, synoviocytes and subchondral b...

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Bibliographic Details
Main Authors: Orlowsky, Eric W, Stabler, Thomas V, Montell, Eulàlia, Vergés, Josep, Kraus, Virginia Byers
Format: Artigo
Language:Inglês
Published: BioMed Central 2014
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4189145/
https://ncbi.nlm.nih.gov/pubmed/25261974
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1471-2474-15-318
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