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Restoration of Cocaine Stimulation and Reward by Reintroducing Wild Type Dopamine Transporter in Adult Knock-in Mice with a Cocaine-Insensitive Dopamine Transporter

In previous studies, we generated knock-in mice with a cocaine-insensitive dopamine transporter (DAT-CI mice) and found cocaine does not stimulate locomotion or produce reward in these mice, indicating DAT inhibition is necessary for cocaine stimulation and reward. However, DAT uptake is reduced in...

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Bibliografiske detaljer
Main Authors: Wu, Haiyin, O’Neill, Brian, Han, Dawn D., Thirtamara-Rajamani, Keerthi, Wang, Yanlin, Gu, Howard H.
Format: Artigo
Sprog:Inglês
Udgivet: 2014
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188717/
https://ncbi.nlm.nih.gov/pubmed/24835281
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuropharm.2014.04.022
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