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Neonatal NMDA Receptor Blockade Disrupts Spike Timing and Glutamatergic Synapses in Fast Spiking Interneurons in a NMDA Receptor Hypofunction Model of Schizophrenia

The dysfunction of parvalbumin-positive, fast-spiking interneurons (FSI) is considered a primary contributor to the pathophysiology of schizophrenia (SZ), but deficits in FSI physiology have not been explicitly characterized. We show for the first time, that a widely-employed model of schizophrenia...

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Bibliografske podrobnosti
Main Authors: Jones, Kevin S., Corbin, Joshua G., Huntsman, Molly M.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188593/
https://ncbi.nlm.nih.gov/pubmed/25290690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109303
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