Cleavage of extracellular matrix in periodontitis: gingipains differentially affect cell adhesion activities of fibronectin and tenascin-C

Gingipains are cysteine proteases that represent major virulence factors of the periodontopathogenic bacterium Porphyromonas gingivalis. Gingipains are reported to degrade extracellular matrix (ECM) of periodontal tissues, leading to tissue destruction and apoptosis. The exact mechanism is not known...

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Bibliographic Details
Main Authors: Ruggiero, Sabrina, Cosgarea, Raluca, Potempa, Jan, Potempa, Barbara, Eick, Sigrun, Chiquet, Matthias
Format: Artigo
Language:Inglês
Published: 2013
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188551/
https://ncbi.nlm.nih.gov/pubmed/23313574
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbadis.2013.01.003
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