Visualization of a substrate‐induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O‐acetylesterase reveals mechanistic conservation in SGNH esterase family members

Peptidoglycan O‐acetylesterase (Ape1), which is required for host survival in Neisseria sp., belongs to the diverse SGNH hydrolase superfamily, which includes important viral and bacterial virulence factors. Here, multi‐domain crystal structures of Ape1 with an SGNH catalytic domain and a newly iden...

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Main Authors: Williams, Allison H., Veyrier, Frédéric J., Bonis, Mathilde, Michaud, Yann, Raynal, Bertrand, Taha, Muhamed‐Kheir, White, Stephen W., Haouz, Ahmed, Boneca, Ivo G.
Formato: Artigo
Idioma:Inglês
Publicado: International Union of Crystallography 2014
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Research Papers
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC4188005/
https://ncbi.nlm.nih.gov/pubmed/25286847
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1399004714016770
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