Ex Vivo Activity of Endoperoxide Antimalarials, Including Artemisone and Arterolane, against Multidrug-Resistant Plasmodium falciparum Isolates from Cambodia

Novel synthetic endoperoxides are being evaluated as new components of artemisinin combination therapies (ACTs) to treat artemisinin-resistant Plasmodium falciparum malaria. We conducted blinded ex vivo activity testing of fully synthetic (OZ78 and OZ277) and semisynthetic (artemisone, artemiside, a...

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Autori principali: Lanteri, Charlotte A., Chaorattanakawee, Suwanna, Lon, Chanthap, Saunders, David L., Rutvisuttinunt, Wiriya, Yingyuen, Kritsanai, Bathurst, Ian, Ding, Xavier C., Tyner, Stuart D.
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2014
Soggetti:
Susceptibility
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187925/
https://ncbi.nlm.nih.gov/pubmed/25049252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02462-14
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