HUWE1 Is a Molecular Link Controlling RAF-1 Activity Supported by the Shoc2 Scaffold

Scaffold proteins play a critical role in controlling the activity of the extracellular signal-regulated kinase 1/2 (ERK1/2) pathway. Shoc2 is a leucine-rich repeat scaffold protein that acts as a positive modulator of ERK1/2 signaling. However, the precise mechanism by which Shoc2 modulates the act...

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Main Authors: Jang, Eun Ryoung, Shi, Ping, Bryant, Jamal, Chen, Jing, Dukhande, Vikas, Gentry, Matthew S., Jang, HyeIn, Jeoung, Myoungkun, Galperin, Emilia
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2014
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4187736/
https://ncbi.nlm.nih.gov/pubmed/25022756
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00811-14
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