Structural Basis for Resistance to Diverse Classes of NAMPT Inhibitors

Inhibiting NAD biosynthesis by blocking the function of nicotinamide phosphoribosyl transferase (NAMPT) is an attractive therapeutic strategy for targeting tumor metabolism. However, the development of drug resistance commonly limits the efficacy of cancer therapeutics. This study identifies mutatio...

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Detaylı Bibliyografya
Asıl Yazarlar: Wang, Weiru, Elkins, Kristi, Oh, Angela, Ho, Yen-Ching, Wu, Jiansheng, Li, Hong, Xiao, Yang, Kwong, Mandy, Coons, Mary, Brillantes, Bobby, Cheng, Eric, Crocker, Lisa, Dragovich, Peter S., Sampath, Deepak, Zheng, Xiaozhang, Bair, Kenneth W., O'Brien, Thomas, Belmont, Lisa D.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2014
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186856/
https://ncbi.nlm.nih.gov/pubmed/25285661
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0109366
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