Smarter vaccine design will circumvent regulatory T cell-mediated evasion in chronic HIV and HCV infection

Despite years of research, vaccines against HIV and HCV are not yet available, due largely to effective viral immunoevasive mechanisms. A novel escape mechanism observed in viruses that cause chronic infection is suppression of viral-specific effector CD4(+) and CD8(+) T cells by stimulating regulat...

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Библиографические подробности
Главные авторы: Moise, Leonard, Terry, Frances, Gutierrez, Andres H., Tassone, Ryan, Losikoff, Phyllis, Gregory, Stephen H., Bailey-Kellogg, Chris, Martin, William D., De Groot, Anne S.
Формат: Artigo
Язык:Inglês
Опубликовано: Frontiers Media S.A. 2014
Предметы:
Microbiology
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4186478/
https://ncbi.nlm.nih.gov/pubmed/25339942
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2014.00502
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