P16.33 AN IN SILICO ESTIMATION OF THE PHARMACOKINETIC PROFILE AND THE DISPOSITION OF GD-DTPA IN BRAIN TUMOR LESIONS OF DIFFERENT VASCULATURE THROUGH PBPK MODELS

Brain tumor lesions (BTL), i.e. high grade gliomas, are known to have a prominence of vasculature, which is promoted through hypoxia mechanisms and differential expression of vascular endothelial growth factor (VEGF). Imaging techniques such as dynamic contrast enhanced magnetic resonance imaging (D...

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Bibliographic Details
Main Authors:	Spanakis, M., Oraiopoulou, M.E., Tzamali, E., Sakkalis, V., Maris, T.G., Papadaki, E., Karantanas, A., Marias, K.
Format:	Artigo
Language:	Inglês
Published:	Oxford University Press 2014
Subjects:	Poster Presentations
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC4185692/ https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/nou174.328
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P16.33 AN IN SILICO ESTIMATION OF THE PHARMACOKINETIC PROFILE AND THE DISPOSITION OF GD-DTPA IN BRAIN TUMOR LESIONS OF DIFFERENT VASCULATURE THROUGH PBPK MODELS

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