Fast and accurate imputation of summary statistics enhances evidence of functional enrichment

Motivation: Imputation using external reference panels (e.g. 1000 Genomes) is a widely used approach for increasing power in genome-wide association studies and meta-analysis. Existing hidden Markov models (HMM)-based imputation approaches require individual-level genotypes. Here, we develop a new m...

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Main Authors: Pasaniuc, Bogdan, Zaitlen, Noah, Shi, Huwenbo, Bhatia, Gaurav, Gusev, Alexander, Pickrell, Joseph, Hirschhorn, Joel, Strachan, David P., Patterson, Nick, Price, Alkes L.
Format: Artigo
Jezik:Inglês
Izdano: Oxford University Press 2014
Teme:
Original Papers
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4184260/
https://ncbi.nlm.nih.gov/pubmed/24990607
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btu416
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