Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor

7,8-dihydroxyflavone (7,8-DHF), a newly identified small molecular TrkB receptor agonist, rapidly activates TrkB in both primary neurons and the rodent brain and mimics the physiological functions of the cognate ligand BDNF. Accumulating evidence supports that 7,8-DHF exerts neurotrophic effects in...

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Autores principales: Liu, Xia, Obianyo, Obiamaka, Chan, Chi Bun, Huang, Junjian, Xue, Shenghui, Yang, Jenny J., Zeng, Fanxing, Goodman, Mark, Ye, Keqiang
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2014
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183797/
https://ncbi.nlm.nih.gov/pubmed/25143381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562561
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