Biochemical and Biophysical Investigation of the Brain-derived Neurotrophic Factor Mimetic 7,8-Dihydroxyflavone in the Binding and Activation of the TrkB Receptor

7,8-dihydroxyflavone (7,8-DHF), a newly identified small molecular TrkB receptor agonist, rapidly activates TrkB in both primary neurons and the rodent brain and mimics the physiological functions of the cognate ligand BDNF. Accumulating evidence supports that 7,8-DHF exerts neurotrophic effects in...

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Gorde:
Xehetasun bibliografikoak
Egile Nagusiak: Liu, Xia, Obianyo, Obiamaka, Chan, Chi Bun, Huang, Junjian, Xue, Shenghui, Yang, Jenny J., Zeng, Fanxing, Goodman, Mark, Ye, Keqiang
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: American Society for Biochemistry and Molecular Biology 2014
Gaiak:
Signal Transduction
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183797/
https://ncbi.nlm.nih.gov/pubmed/25143381
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.562561
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