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Group X Secretory Phospholipase A(2) Regulates Insulin Secretion through a Cyclooxygenase-2-dependent Mechanism
Group X secretory phospholipase A(2) (GX sPLA(2)) potently hydrolyzes membrane phospholipids to release arachidonic acid (AA). While AA is an activator of glucose-stimulated insulin secretion (GSIS), its metabolite prostaglandin E2 (PGE2) is a known inhibitor. In this study, we determined that GX sP...
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Main Authors: | , , , , |
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פורמט: | Artigo |
שפה: | Inglês |
יצא לאור: |
American Society for Biochemistry and Molecular Biology
2014
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נושאים: | |
גישה מקוונת: | https://ncbi.nlm.nih.gov/pmc/articles/PMC4183781/ https://ncbi.nlm.nih.gov/pubmed/25122761 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M114.591735 |
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