A Potent α/β-Peptide Analogue of GLP-1 with Prolonged Action in Vivo

[Image: see text] Glucagon-like peptide-1 (GLP-1) is a natural agonist for GLP-1R, a G protein-coupled receptor (GPCR) on the surface of pancreatic β cells. GLP-1R agoinsts are attractive for treatment of type 2 diabetes, but GLP-1 itself is rapidly degraded by peptidases in vivo. We describe a desi...

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Главные авторы: Johnson, Lisa M., Barrick, Stacey, Hager, Marlies V., McFedries, Amanda, Homan, Edwin A., Rabaglia, Mary E., Keller, Mark P., Attie, Alan D., Saghatelian, Alan, Bisello, Alessandro, Gellman, Samuel H.
Формат: Artigo
Язык:Inglês
Опубликовано: American Chemical Society 2014
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC4183665/
https://ncbi.nlm.nih.gov/pubmed/25191938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/ja507168t
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